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KMID : 1161520200240010034
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Animal Cells and Systems
2020 Volume.24 No. 1 p.34 ~ p.43
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Ethylparaben induces apoptotic cell death in human placenta BeWo cells via the Caspase-3 pathway
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Kim Mi-Jin
Kim Chul-Hong
An Mi-Jin
Lee Ju-Hyun
Shin Geun-Seup
Song Mi-Na
Kim Jung-Woong
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Abstract
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Parabens are generally used as preservatives in foods, pharmaceuticals, and various other commercial products. Among them, ethylparaben has weaker estrogenic characteristics than endogenous estrogen. However, growing evidence indicates that ethylparaben has an adverse effect on various human tissues. Here, we investigated whether ethylparaben induces cell death by affecting cell viability, cell proliferation, cell cycle, and apoptosis using the human placenta cell line BeWo. Ethylparaben significantly decreased cell viability in a dose-dependent manner. It caused cell cycle arrest at sub-G1 by reducing the expression of cyclin D1, whereas it decreased the cell proportion at the G0/G1 and S phases. Furthermore, we verified that ethylparaben induces apoptotic cell death by enhancing the activity of Caspase-3. Taken together, our results suggest that ethylparaben exerts cytotoxic effects in human placental BeWo cells via cell cycle arrest and apoptotic pathways.
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KEYWORD
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Ethylparaben, apoptosis, cell cycle arrest, human placenta cells, BeWo
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